Taking certain drugs while you’re also taking statins might increase your risk of muscle damage. These drugs include: fibrates; nicotinic acid; the antifungals Sporonox (itraconazole), Nizoral (ketoconazole), and anything in the azole class of drug; antibiotics such as erythromycin and clarithromycin; the immunosuppressant Sandimmune (cyclosporine); HIV protease inhibitors; antidepressants such as Serzone (nefazodone); the beta-blockers Calan (verapamil) and |soptin (verapamil); and the anti-arrhythmia drug Cordarone IV (amiodarone).